Neocortical development
From neurov.is/on
[edit] Flashcards
| Column 1 | Column 2 (memorize) |
|---|---|
| The pre-plate layer of the neocortex splits into what layers? What layer forms between? | It splits into the marginal zone (superficial) and the subplate (deep). The cortical plate forms between. |
| Is layer 6 the oldest or the newest layer that was formed? | Trick question, it is the second to the oldest. Layer 1 is an anomaly and was actually created before layer 6. |
| What is the simplified developmental "tree" of neuro-epithelial stem cells? | 
|
| What happens when Notch is overexpressed in neocortex dev? (simplified) | Over-maintenance of the stem cell population, too much glia, and almost no formation of neurons. |
| What happens when Notch is blocked in neocortex dev? (simplified) | An temporary increase in the number of neurons and a blockage of glia and adult neural stem cells (which leads to an overall reduction in the number of neurons). |
| What are the more complex developmental "tree" of neuro-epithelial stem cells? | Radial glial can generate neurons indirectly through Neuroblasts
|
| What is the maintenance of radial glial cells model? | It states that radial glial cells express the Notch receptor and that the migratory neurons express delta, such that the neuronal-fate is inhibited in the RG. |
| What is different in reeler mouse mutants? What causes this? | The laminar organization is reversed from normal (older cells are most superficial). This is caused because neurons lost their ability to cease migration and each new wave would just pile behind the older waves. |
| What type of cells typically derived from ganglionic eminences? | Interneurons (=GABAergic neurons?) and oligodendrocytes. These are not thought to use RG scaffolding. |
[edit] Final view
[edit] NeuroCog Lectures
| Date | Time | Topic | Instructor |
|---|---|---|---|
| Fri 10/23 | 1:00 | Lab 3 Glia | |
| Fri 10/30 | 10:45 | Dendritic integration | Niebur |
| Fri 10/30 | 1:00 | Fundamentals of neural coding | Hsiao |
| Mon 11/2 | 10:45 | Correlation of neurophysiology & psychophysics | Hsiao |
| Wed 11/4 | 10:45 | Neural induction | Marsh-Armstrong |
| Fri 11/6 | 10:45 | Neural cell fate specification | Gaiano |
| Fri 11/6 | 1:00 | NT: In vivo recording | Hsiao |
| Mon 11/9 | 10:45 | Neocortical development | Gaiano |
| Wed 11/11 | 10:45 | Axon guidance and regeneration I | Kolodkin |
| Wed 11/11 | 1:00 | Inverterbrate model organisms (note: Wed afternoon class) | Kolodkin |
| Fri 11/13 | 10:45 | Axon guidance and regeneration II | Ming |
| Fri 11/13 | 1:00 | Lab 4 Embryology | |
| Mon 11/16 | 10:45 | Neural stem cells and adult neurogenesis | Song |
| Mon 11/16 | Mini-review II assigned | ||
| Wed 11/18 | 10:45 | NT: gene expression analysis (note: 1.5 hour class) | Blackshaw |
| Fri 11/20 | 10:45 | Neuronal death during development | Ginty |
| Fri 11/20 | 1:00 | Lab 5 Brainstem and Spinal Cord | |
| Mon 11/23 | 10:45 | Neuronal growth factors | Ginty |
| Wed 11/25 | 10:45 | Synaptogenesis and synapse elimination | Sockanathan |
| Thu 11/26 | THANKSGIVING HOLIDAY - NO CLASS | ||
| Fri 11/27 | THANKSGIVING HOLIDAY - NO CLASS | ||
| Mon 11/30 | 10:45 | NT: protein techniques (note: 1.5 hour class) | Blackshaw |
| Wed 12/2 | 10:45 | Speech production, neural representation, and perception | Young |
| Wed 12/2 | 1:00 | NT: mouse genetic (note: Wednesday afternoon class) | Zack |
| Fri 12/4 | 10:45 | Sound localization | Young |
| Fri 12/4 | 1:00 | Lab 6 Auditory system | |
| Mon 12/7 | 10:45 | Neural basis of language | Hillis |
| Mon 12/7 | 1:00 | Mini-review II due (note: Monday afternoon class) | Gaiano, Marsh-Armstrong |
| Wed 12/9 | 10:45 | Mechanotransduction by the inner ear | Fuchs |
| Fri 12/11 | 10:45 | Bird song lecture | Ball |
| Fri 12/11 | 1:00 | Central auditory processing | Wang |
| Mon 12/14 | 10:45 | Synaptic signaling in the cochlea | Fuchs |
| Wed 12/16 | 10:45 | REVIEW SESSION | TAs |
| Fri 12/18 | 9:00 | FINAL EXAM (Material 10/27 - 12/17) |
