Synaptogenesis and synapse elimination
From neurov.is/on
[edit] Flashcards
| Column 1 | Column 2 (memorize) |
|---|---|
| Name and describe 3 molecules involved in post-synaptic differentiation in central synapses. | NARP induces clustering of AMPA receptors. Eph receptor tyrosine kinases potentially induces clustering of NMDA receptors. Cadherins, present on pre and postsynaptic membranes, may establish cytoskeletal stabilizations and specificity on pre and postsynaptic contact. |
| Describe three events that require interactions between the muscle and nerve that are required for the final NMJ. | 1). Clustering of AChR at postsynaptic sites, which require agrin, Musk, and Rapsyn. 2). Dispersion of extrasynaptic AChR, which is dependent on electrical activity, ACh, and Cdk5. 3). Synaptic elimination |
| What are the 3 sequential processes for the development of synapses? | 1). Target recognition 2). synaptic differentiation and 3). stabilization of destabilization. |
| What are the three main events that characterizes the differentiation of the neuromuscular junction (classical view)? | 1. Clustering of diffuse Ach Receptors at the postsynaptic membrane 2. Enhancement of AchR transcription at intrasynaptic sites and 3. Repression of AchR transcription at extrasynaptic sites. |
| Agrin GOF | Injection of recombinant agrin into muscles or denervated muscle fibers results in patches of agrin on the surfice of muscle with postsynaptic apparatus. |
| Agrin LOF | Agrin KO mice have postsynaptic differentiation impaired. Few AchR clusters. |
| What is the Agrin hypothesis? | That agrin is the master nerve-derived initiator of postsynaptic differentiation. |
| What is the current hypothesis for the clustering of AchR? |
First, Musk and rapsyn leads to the formation of protosynapses. The second step is nerve-mediated and requires neuronal agrin which mediates the refinement of the synapses by elimination of protosynapses. |
| Lrp4 | A receptor for Agrin and forms a complex with MuSK. |
| What is the current speculation on the transcription of postsynaptic transcription of AChR? | Agrin is responsible for transcription of AchRs in subsynaptic nuclei. |
| What molecule is important for the dispersal of AChR? | Cdk5 |
| What are some of the possible signals for synapse-specific elimination and/or strengthening? | synaptotrophins, synaptotoxins or synaptomedins |
| Give 3 examples of important molecules for the basal lamina. || acetylcholinesterase, agrin and neuregulin.
|-
[edit] NeuroCog Lectures
| Date | Time | Topic | Instructor |
|---|---|---|---|
| Fri 10/23 | 1:00 | Lab 3 Glia | |
| Fri 10/30 | 10:45 | Dendritic integration | Niebur |
| Fri 10/30 | 1:00 | Fundamentals of neural coding | Hsiao |
| Mon 11/2 | 10:45 | Correlation of neurophysiology & psychophysics | Hsiao |
| Wed 11/4 | 10:45 | Neural induction | Marsh-Armstrong |
| Fri 11/6 | 10:45 | Neural cell fate specification | Gaiano |
| Fri 11/6 | 1:00 | NT: In vivo recording | Hsiao |
| Mon 11/9 | 10:45 | Neocortical development | Gaiano |
| Wed 11/11 | 10:45 | Axon guidance and regeneration I | Kolodkin |
| Wed 11/11 | 1:00 | Inverterbrate model organisms (note: Wed afternoon class) | Kolodkin |
| Fri 11/13 | 10:45 | Axon guidance and regeneration II | Ming |
| Fri 11/13 | 1:00 | Lab 4 Embryology | |
| Mon 11/16 | 10:45 | Neural stem cells and adult neurogenesis | Song |
| Mon 11/16 | Mini-review II assigned | ||
| Wed 11/18 | 10:45 | NT: gene expression analysis (note: 1.5 hour class) | Blackshaw |
| Fri 11/20 | 10:45 | Neuronal death during development | Ginty |
| Fri 11/20 | 1:00 | Lab 5 Brainstem and Spinal Cord | |
| Mon 11/23 | 10:45 | Neuronal growth factors | Ginty |
| Wed 11/25 | 10:45 | Synaptogenesis and synapse elimination | Sockanathan |
| Thu 11/26 | THANKSGIVING HOLIDAY - NO CLASS | ||
| Fri 11/27 | THANKSGIVING HOLIDAY - NO CLASS | ||
| Mon 11/30 | 10:45 | NT: protein techniques (note: 1.5 hour class) | Blackshaw |
| Wed 12/2 | 10:45 | Speech production, neural representation, and perception | Young |
| Wed 12/2 | 1:00 | NT: mouse genetic (note: Wednesday afternoon class) | Zack |
| Fri 12/4 | 10:45 | Sound localization | Young |
| Fri 12/4 | 1:00 | Lab 6 Auditory system | |
| Mon 12/7 | 10:45 | Neural basis of language | Hillis |
| Mon 12/7 | 1:00 | Mini-review II due (note: Monday afternoon class) | Gaiano, Marsh-Armstrong |
| Wed 12/9 | 10:45 | Mechanotransduction by the inner ear | Fuchs |
| Fri 12/11 | 10:45 | Bird song lecture | Ball |
| Fri 12/11 | 1:00 | Central auditory processing | Wang |
| Mon 12/14 | 10:45 | Synaptic signaling in the cochlea | Fuchs |
| Wed 12/16 | 10:45 | REVIEW SESSION | TAs |
| Fri 12/18 | 9:00 | FINAL EXAM (Material 10/27 - 12/17) |
