Neocortical development
From neurov.is/on
Flashcards
| Column 1 | Column 2 (memorize) |
|---|---|
| The pre-plate layer of the neocortex splits into what layers? What layer forms between? | It splits into the marginal zone (superficial) and the subplate (deep). The cortical plate forms between. |
| Is layer 6 the oldest or the newest layer that was formed? | Trick question, it is the second to the oldest. Layer 1 is an anomaly and was actually created before layer 6. |
| What is the simplified developmental "tree" of neuro-epithelial stem cells? | 
|
| What happens when Notch is overexpressed in neocortex dev? (simplified) | Over-maintenance of the stem cell population, too much glia, and almost no formation of neurons. |
| What happens when Notch is blocked in neocortex dev? (simplified) | An temporary increase in the number of neurons and a blockage of glia and adult neural stem cells (which leads to an overall reduction in the number of neurons). |
| What are the more complex developmental "tree" of neuro-epithelial stem cells? | Radial glial can generate neurons indirectly through Neuroblasts
|
| What is the maintenance of radial glial cells model? | It states that radial glial cells express the Notch receptor and that the migratory neurons express delta, such that the neuronal-fate is inhibited in the RG. |
| What is different in reeler mouse mutants? What causes this? | The laminar organization is reversed from normal (older cells are most superficial). This is caused because neurons lost their ability to cease migration and each new wave would just pile behind the older waves. |
| What type of cells typically derived from ganglionic eminences? | Interneurons (=GABAergic neurons?) and oligodendrocytes. These are not thought to use RG scaffolding. |
Final view
